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Repurposing of clinical-stage FLT3 inhibitor HYML-122 as a potent RIPK2 inhibitor for the treatment of inflammatory bowel disease

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Reduced CD4 + ,CD25 T cell sensitivity to the suppressive function of CD4 + ,CD25 high ,CD127 /low regulatory T cells in patients with active systemic lupus erythematosus

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Thus, to maximize therapeutic outcomes, novel designs are required to advance the facile integration of different therapeutics onto platelet carriers, progressively improve both binding and penetration in atherosclerotic lesions, and ensure on-demand drug delivery to plaque macrophages

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